Home > CALYPSO Nitrogen gas generators for LC-MS(MS)
Any LC-MS (Liquid Chromatography Mass Spectrometry) requires a reliable source of Nitrogen gas and to meet the specific market demands, F-DGSi’s very first gas generator that was manufactured was a Nitrogen generator. With more than 15 years of experience, our CALYPSO range has become the benchmark. Thanks to the robust architecture and stable operation helping the various manufacturers LC-MS to run continuously 24*7. CALYPSO comes in two technologies, you can chose depending on the purity and sensitivity requested by your analysis. The two technologies available are called PSA and Membrane.
Single and Multiple Gas for CALYPSO


































The PSA absorption process utilizes carbon molecular sieve filtration (CMS). The CMS retains molecules of O2, CO2, and H2O, as well as hydrocarbons from the atmosphere, while allowing nitrogen to pass through. CMS columns cycle between purification and regeneration modes to ensure continuous nitrogen production. The process is thus cyclical and fully automated, offering nitrogen purities exceeding 99.9995% and an average column lifespan generally exceeding 10 years. The advantages of PSA are:
The membrane technology utilizes semi-permeable polymer hollow fibers that enable molecular separation. Small molecules like O2 and carbon dioxide diffuse through the membrane pores, while the larger nitrogen molecules remain trapped in the membrane flow.
This is a simple filtration technique that maintains nitrogen purity below 99.5%. The membrane itself has a lifespan of less than 5 years because it cannot be regenerated. In contrast, PSA (Pressure Swing Adsorption) technology can guarantee a lifespan of 10 years. To protect the membrane from hydrocarbons, it is also advisable to add an activated carbon filter.